Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines

Nature. 1984 Oct 25-31;311(5988):727-33. doi: 10.1038/311727a0.


The most JH-proximal VH gene segments are used highly preferentially to form VHDJH rearrangements in pre-B-cell lines. This result demonstrates that the rate at which immunoglobulin VH gene segments recombine is influenced by their chromosomal organization, and that the initial repertoire of VH genes expressed in pre-B cells is strikingly different from that seen in mature populations.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • B-Lymphocytes / immunology*
  • Base Sequence
  • Bone Marrow / immunology
  • DNA Restriction Enzymes
  • Fetus
  • Genes*
  • Hybridomas / immunology
  • Immunoglobulin J-Chains / genetics*
  • Immunoglobulin Variable Region / genetics*
  • Liver / immunology
  • Mice
  • Mice, Inbred BALB C


  • Immunoglobulin J-Chains
  • Immunoglobulin Variable Region
  • DNA Restriction Enzymes

Associated data

  • GENBANK/K02886
  • GENBANK/K02887
  • GENBANK/K02888
  • GENBANK/K02889
  • GENBANK/K02890