Effect of microelectrophoretically applied corticosterone on raphe neurones in the rat

Neurosci Lett. 1984 Sep 7;50(1-3):307-11. doi: 10.1016/0304-3940(84)90504-4.

Abstract

The effect of microelectrophoretic application of corticosterone (CS) on single neurones of raphe nuclei (RN) were investigated in rats under urethane anaesthesia. Ejecting currents generally ranged from 5 to 40 nA. CS produced an excitatory effect in 61% and no effect in 39% of the neurones. None of the 54 neurones studied was inhibited by CS. These quite homogeneous data support the hypothesis that RN are involved in the regulation of most of the nervous functions in which glucocorticoid hormones have been implicated.

MeSH terms

  • Action Potentials / drug effects
  • Adrenocorticotropic Hormone / metabolism
  • Animals
  • Corticosterone / pharmacology*
  • Hypothalamus / physiology
  • Iontophoresis
  • Male
  • Neural Pathways / physiology
  • Pain / physiopathology
  • Raphe Nuclei / drug effects*
  • Raphe Nuclei / physiology
  • Rats
  • Rats, Inbred Strains

Substances

  • Adrenocorticotropic Hormone
  • Corticosterone