P-element transformation with period locus DNA restores rhythmicity to mutant, arrhythmic Drosophila melanogaster

Cell. 1984 Dec;39(2 Pt 1):369-76. doi: 10.1016/0092-8674(84)90015-1.


Mutations at the period (per) locus of Drosophila melanogaster disrupt several biological rhythms. Molecular cloning of DNA sequences encompassing the per+ locus has allowed germ-line transformation experiments to be carried out. Certain subsegments of the per region, transduced into the genome of arrhythmic pero flies, restore rhythmicity in circadian locomotor behavior and the male's courtship song.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Circadian Rhythm*
  • Cloning, Molecular
  • DNA Restriction Enzymes
  • Drosophila melanogaster / genetics*
  • Drosophila melanogaster / physiology
  • Female
  • Genes
  • Male
  • Mutation*
  • Phenotype
  • Sexual Behavior, Animal
  • Transformation, Genetic*
  • Vocalization, Animal


  • DNA Restriction Enzymes