The Neu Oncogene: An erb-B-related Gene Encoding a 185,000-Mr Tumour Antigen

Nature. 1984 Dec 6-12;312(5994):513-6. doi: 10.1038/312513a0.

Abstract

A series of rat neuro/glioblastomas all contain the same transforming gene (neu) which induces synthesis of a tumour antigen of relative molecular mass (Mr) 185,000 (p185). The neu oncogene bears homology to erb-B and the tumour antigen, p185, is serologically related to the epidermal growth factor (EGF) receptor. The two proteins, EGF receptor and p185 appear to be distinct, as they coexist in nontransformed Rat-1 cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antigens, Neoplasm / genetics*
  • Cross Reactions
  • ErbB Receptors
  • Glioma / genetics
  • Glioma / immunology*
  • Molecular Weight
  • Neuroblastoma / genetics
  • Neuroblastoma / immunology*
  • Oncogenes*
  • Rats
  • Receptors, Cell Surface / genetics*
  • Receptors, Cell Surface / immunology

Substances

  • Antigens, Neoplasm
  • Receptors, Cell Surface
  • ErbB Receptors