Hyperkeratinization, corneocyte cohesion, and alpha hydroxy acids

J Am Acad Dermatol. 1984 Nov;11(5 Pt 1):867-79. doi: 10.1016/s0190-9622(84)80466-1.

Abstract

Hyperkeratinization is a primary or fundamental event in a majority of today's skin disorders. Hyperkeratinization is usually the result of decreased desquamation due to increased corneocyte cohesion. Strength of corneocyte cohesion is determined by strength of intercellular bonding. Intercellular bonding is weakened by water and diminished by retinoids and alpha hydroxy acids (AHAs). Conversely, bonding is strengthened or enhanced by dehydration, vitamin A deficiency, and some alpha acetoxy acids (AAAs). Agents that control or modify keratinization can be useful in treatment of many skin disorders.

MeSH terms

  • Animals
  • Extracellular Matrix / drug effects
  • Humans
  • Hydroxy Acids / therapeutic use*
  • Ichthyosis / drug therapy
  • Keratosis / drug therapy*
  • Keratosis / pathology
  • Phosphoric Monoester Hydrolases / metabolism
  • Retinoids / therapeutic use
  • Skin / drug effects*
  • Skin / pathology
  • Sulfatases / metabolism
  • Vitamin A / metabolism
  • Vitamin A Deficiency / complications
  • Water-Electrolyte Balance / drug effects

Substances

  • Hydroxy Acids
  • Retinoids
  • Vitamin A
  • Phosphoric Monoester Hydrolases
  • Sulfatases