The Olfactory Bulbectomized Rat as a Model of Depression

Pol J Pharmacol Pharm. Sep-Oct 1984;36(5):561-9.


The behavioural effects of bilateral olfactory bulbectomy in the rat are summarized and evidence presented to show that the deficits in active and passive avoidance behaviour, and hyperactivity in a novel stressful environment, can be specifically attenuated by chronic administration of antidepressants. The usefulness of the bulbectomized rat model in the detection of potential antidepressants and in giving an insight into the possible mechanisms of action of these drugs is summarized.

Publication types

  • Review

MeSH terms

  • Animals
  • Antidepressive Agents / therapeutic use*
  • Avoidance Learning / physiology
  • Behavior, Animal / physiology
  • Brain / metabolism
  • Conditioning, Classical / physiology
  • Depressive Disorder* / drug therapy
  • Depressive Disorder* / metabolism
  • Disease Models, Animal*
  • Humans
  • Olfactory Bulb / physiology*
  • Rats
  • Rats, Inbred Strains
  • Synaptic Transmission
  • gamma-Aminobutyric Acid / metabolism


  • Antidepressive Agents
  • gamma-Aminobutyric Acid