The role of hormone receptors and GTP-regulatory proteins in membrane transduction

Nature. 1980 Mar 6;284(5751):17-22. doi: 10.1038/284017a0.


Cell membrane receptors for hormones and neurotransmitters form oligomeric complexes with GTP-regulatory proteins and inhibit the latter from reacting with GTP. Hormones and neurotransmitters act by releasing the inhibitory constraints imposed by the receptors, thus allowing the GTP-regulatory proteins to interact with and control the activity of enzymes such as adenylate cyclase. This theory may apply generally to membrane signal transduction involving surface receptors.

MeSH terms

  • Adenylyl Cyclase Inhibitors
  • Adenylyl Cyclases / metabolism*
  • Animals
  • Carrier Proteins / physiology
  • Cyclic AMP / metabolism
  • Enzyme Activation
  • Guanosine Triphosphate / physiology*
  • Humans
  • Macromolecular Substances
  • Membrane Proteins / physiology
  • Neurotransmitter Agents / pharmacology
  • Receptors, Cell Surface / physiology
  • Receptors, Drug / physiology*
  • Receptors, Neurotransmitter / physiology


  • Adenylyl Cyclase Inhibitors
  • Carrier Proteins
  • Macromolecular Substances
  • Membrane Proteins
  • Neurotransmitter Agents
  • Receptors, Cell Surface
  • Receptors, Drug
  • Receptors, Neurotransmitter
  • Guanosine Triphosphate
  • Cyclic AMP
  • Adenylyl Cyclases