Abstract
Colchicine effect has been tested on rat liver plasma membrane-bound enzymes after in vitro or in vivo treatment. It appears that the in vitro treatment does not affect 5'-nucleotidase, Mg2+-ATPase and (Na+ + K+)-ATPase, whereas adenylate cyclase is sensitive to both in vitro and in vivo treatment, the latter condition being also effective for 5'-nucleotidase.
MeSH terms
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Adenosine Triphosphatases / metabolism
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Adenylyl Cyclases / metabolism
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Animals
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Ca(2+) Mg(2+)-ATPase
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Cell Membrane / drug effects
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Cell Membrane / enzymology*
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Colchicine / pharmacology*
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Glucagon / pharmacology
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Liver / enzymology*
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Lumicolchicines / pharmacology
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Male
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Nucleotidases / metabolism
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Rats
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Sodium-Potassium-Exchanging ATPase / metabolism
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Spectrometry, Fluorescence
Substances
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Lumicolchicines
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Glucagon
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Nucleotidases
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Adenosine Triphosphatases
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Ca(2+) Mg(2+)-ATPase
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Adenylyl Cyclases
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Sodium-Potassium-Exchanging ATPase
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Colchicine