Effect of colchicine on rat liver plasma membrane

Biochim Biophys Acta. 1980 Mar 13;596(3):451-5. doi: 10.1016/0005-2736(80)90133-9.

Abstract

Colchicine effect has been tested on rat liver plasma membrane-bound enzymes after in vitro or in vivo treatment. It appears that the in vitro treatment does not affect 5'-nucleotidase, Mg2+-ATPase and (Na+ + K+)-ATPase, whereas adenylate cyclase is sensitive to both in vitro and in vivo treatment, the latter condition being also effective for 5'-nucleotidase.

MeSH terms

  • Adenosine Triphosphatases / metabolism
  • Adenylyl Cyclases / metabolism
  • Animals
  • Ca(2+) Mg(2+)-ATPase
  • Cell Membrane / drug effects
  • Cell Membrane / enzymology*
  • Colchicine / pharmacology*
  • Glucagon / pharmacology
  • Liver / enzymology*
  • Lumicolchicines / pharmacology
  • Male
  • Nucleotidases / metabolism
  • Rats
  • Sodium-Potassium-Exchanging ATPase / metabolism
  • Spectrometry, Fluorescence

Substances

  • Lumicolchicines
  • Glucagon
  • Nucleotidases
  • Adenosine Triphosphatases
  • Ca(2+) Mg(2+)-ATPase
  • Adenylyl Cyclases
  • Sodium-Potassium-Exchanging ATPase
  • Colchicine