Production of pseudodiabetic renal glomerular changes in mice after repeated injections of glucosylated proteins

Lancet. 1980 Apr 5;1(8171):738-40. doi: 10.1016/s0140-6736(80)91234-9.

Abstract

Plasma proteins glucosylated in vitro were injected repeatedly into 7 mice. A group of 4 was given multiple injections of non-glucosylated plasma proteins and another 10 were untreated. 5 of 7 mice given glucosylated proteins had glomerular-basement-membrane thickening on electron microscopical examination. This feature is characteristic of human and experimental diabetic renal disease. These results suggest that there may be a link between plasma-protein glucosylation and diabetic nephropathy.

MeSH terms

  • Animals
  • Basement Membrane / blood supply
  • Basement Membrane / drug effects
  • Basement Membrane / ultrastructure
  • Blood Glucose / analysis*
  • Capillaries / ultrastructure
  • Diabetes Mellitus, Experimental / chemically induced*
  • Diabetic Nephropathies / chemically induced*
  • Diabetic Nephropathies / metabolism
  • Glycosides / administration & dosage*
  • Hemoglobin A / administration & dosage
  • Hemoglobin A / analogs & derivatives*
  • Injections
  • Kidney Glomerulus / drug effects
  • Mice
  • Mice, Inbred BALB C

Substances

  • Blood Glucose
  • Glycosides
  • Hemoglobin A