The pathophysiology of extrapyramidal side-effects of neuroleptic drugs

Psychol Med. 1980 Feb;10(1):55-72. doi: 10.1017/s003329170003960x.

Abstract

The mechanisms responsible for the production of major extrapyramidal side-effects (parkinsonism, akathisia, acute dystonic reactions, chronic tardive dyskinesias) are reviewed in the light of the complex effects of these drugs on cerebral dopamine systems.

Publication types

  • Review

MeSH terms

  • Antipsychotic Agents / adverse effects*
  • Basal Ganglia Diseases / chemically induced*
  • Corpus Striatum / drug effects
  • Dopamine / metabolism
  • Dopamine / physiology
  • Dyskinesia, Drug-Induced / etiology
  • Dystonia / chemically induced
  • Humans
  • Parkinson Disease, Secondary / chemically induced
  • Receptors, Dopamine / drug effects
  • Stereotyped Behavior / drug effects
  • Substance Withdrawal Syndrome / etiology
  • Sympatholytics / pharmacology

Substances

  • Antipsychotic Agents
  • Receptors, Dopamine
  • Sympatholytics
  • Dopamine