Abstract
The mechanisms responsible for the production of major extrapyramidal side-effects (parkinsonism, akathisia, acute dystonic reactions, chronic tardive dyskinesias) are reviewed in the light of the complex effects of these drugs on cerebral dopamine systems.
MeSH terms
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Antipsychotic Agents / adverse effects*
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Basal Ganglia Diseases / chemically induced*
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Corpus Striatum / drug effects
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Dopamine / metabolism
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Dopamine / physiology
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Dyskinesia, Drug-Induced / etiology
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Dystonia / chemically induced
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Humans
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Parkinson Disease, Secondary / chemically induced
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Receptors, Dopamine / drug effects
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Stereotyped Behavior / drug effects
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Substance Withdrawal Syndrome / etiology
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Sympatholytics / pharmacology
Substances
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Antipsychotic Agents
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Receptors, Dopamine
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Sympatholytics
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Dopamine