Treatment of acute respiratory failure with low-frequency positive-pressure ventilation and extracorporeal removal of CO2

Lancet. 1980 Aug 9;2(8189):292-4. doi: 10.1016/s0140-6736(80)90237-8.


Terminal respiratory failure was reversed in three patients with a combination of extra-corporeal CO2 removal through a membrane lung and oxygen diffusion into the diseased lungs between mechanical breaths induced at a frequency of 2-3/min. The technique seems to prevent the pulmonary barotrauma and extrapulmonary derangements caused by conventional mechanical ventilation.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Adult
  • Artificial Organs
  • Carbon Dioxide / blood*
  • Extracorporeal Circulation / instrumentation*
  • Female
  • Humans
  • Intermittent Positive-Pressure Ventilation / methods*
  • Lung Compliance
  • Middle Aged
  • Oxygenators, Membrane
  • Positive-Pressure Respiration / methods*
  • Pregnancy
  • Respiratory Insufficiency / therapy*
  • Tidal Volume


  • Carbon Dioxide