Pancreatic islet-cell damage in children with fatal viral infections

Lancet. 1980 Aug 16;2(8190):354-8.

Abstract

The pancreases from 250 children with fatal infections caused by at least fourteen different viruses were examined for lesions in the islets of Langerhans. Viral cytopathology was found in 4 of 7 cases of Coxsackievirus B infection, 20 of 45 cases of cytomegalovirus infection, 2 of 14 cases of varicella-zoster infection, and 2 of 45 cases of congenital rubella. Destruction of beta cells and acute and chronic inflammatory infiltrates were found in islets from cases with Coxsackievirus B infections. Characteristic inclusion bodies were observed in islets from cases with cytomegalovirus and varicella-zoster infections. This survey provides further evidence that some viruses can infect and damage human beta cells.

Publication types

  • Case Reports

MeSH terms

  • Arbovirus Infections / pathology
  • Child
  • Diabetes Mellitus, Type 1 / microbiology
  • Female
  • Hepatitis, Viral, Human / pathology
  • Herpes Simplex / pathology
  • Humans
  • Inclusion Bodies, Viral / microbiology
  • Infant
  • Infant, Newborn
  • Islets of Langerhans / microbiology*
  • Islets of Langerhans / pathology
  • Male
  • Picornaviridae Infections / pathology
  • Poxviridae Infections / pathology
  • Respirovirus Infections / pathology
  • Virus Diseases / pathology*