Narcotic analgesics and stereotyped behaviour in mice

Naunyn Schmiedebergs Arch Pharmacol. 1980 Jul;312(3):225-7. doi: 10.1007/BF00499150.

Abstract

In this paper we have studied the effects of morphine, codeine, fentanyl, pentazocine, etorphine and fluphenazine (all drugs injected i.p.) on stereotyped behaviour induced by methylphenidate 60 mg/kg i.p., as well as induced by apomorphine 5 mg/kg s.c. in mice. It was found that all used analgesics and fluphenazine dose--dependently inhibited the intensity of methylphenidate--induced gnawing in mice. This effect of analgesics, but not that of fluphenazine was antagonized by naloxone (0.8 mg/kg i.p.) and nalorphine (10 mg/kg i.p.). Climbing behaviour induced by apomorphine was not reduced by narcotic analgesics, but fluphenazine inhibited this effect dose--dependently. These findings give the behavioural support that analgesics applied have antidopaminergic activity in mice.

MeSH terms

  • Analgesics, Opioid / pharmacology*
  • Animals
  • Apomorphine / pharmacology
  • Behavior / drug effects*
  • Dose-Response Relationship, Drug
  • Drug Interactions
  • Fluphenazine / pharmacology
  • Humans
  • Methylphenidate / pharmacology
  • Mice
  • Stereotyped Behavior / drug effects*

Substances

  • Analgesics, Opioid
  • Methylphenidate
  • Apomorphine
  • Fluphenazine