The ontogeny of the neural crest in avian embryo chimaeras

Nature. 1980 Aug 14;286(5774):663-9. doi: 10.1038/286663a0.


The migration and subsequent development of autonomic ganglion cell precursors can be followed in suitably constructed chimaeric quail-chick embryos, thanks to the distinctive structures of quail and chick interphase nuclei. The decisive role of environmental factors arising from non-neuronal tissues on the chemical differentiation of neurones was demonstrated together with the lability of their phenotype during ontogeny.

MeSH terms

  • Animals
  • Autonomic Nervous System / embryology*
  • Cell Differentiation
  • Cell Movement
  • Cells, Cultured
  • Chickens
  • Chimera
  • Coturnix
  • Embryonic Induction
  • Neural Crest / cytology*
  • Neurotransmitter Agents / metabolism


  • Neurotransmitter Agents