Ketazolam and diazepam in anxiety: a controlled study

J Clin Pharmacol. 1980 Oct;20(10):581-9. doi: 10.1002/j.1552-4604.1980.tb01673.x.


Ketazolam (both in once-daily and three-times-daily dosing), diazepam, and placebo were compared for effectiveness in relieving anxious symptomatology in a clinical trial conducted with a total of 222 anxious, non-psychotic outpatients. Results indicated that improvement occurred early in treatment, that ketazolam was equally effective in both once-daily and three-times-daily dosing, and that ketazolam was similar in effect to diazepam. Ketazolam (both once-daily and three-times-daily) and diazepam were significantly (P < 0.05) better than placebo in alleviating symptoms of anxiety, as measured by the Hamilton Anxiety Scale, the Covi Anxiety Scale, and a physician-rated measure of global improvement.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Anti-Anxiety Agents / adverse effects
  • Anti-Anxiety Agents / therapeutic use*
  • Anxiety / drug therapy*
  • Benzodiazepines*
  • Benzodiazepinones / adverse effects
  • Benzodiazepinones / therapeutic use*
  • Diazepam / adverse effects
  • Diazepam / therapeutic use*
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Middle Aged
  • Psychiatric Status Rating Scales


  • Anti-Anxiety Agents
  • Benzodiazepinones
  • Benzodiazepines
  • ketazolam
  • Diazepam