Intracarotidal injection of beta-adrenergic blocking agents: variations in the carotid sinus baro- and chemoreceptor activity

Res Commun Chem Pathol Pharmacol. 1980 Nov;30(2):211-20.

Abstract

The intracarotidal injection of some bet-adrenergic blocking agents (dl-acebutolol, dl-, l-, d-alprenolol, dl-bunitrolol, dl-buthoxamine, dl-, l-, d-INPEA, dl-Ko 592, dl-metoprolol, dl-oxprenolol, dl-propranolol, dl-tolamolol) in anesthetized and bivagotomized dogs reduced the arterial blood pressure and the baro- and chemoreceptor activity. These effects seem to be mediated by an interaction with central nervous, cardiovascular and respiratory structures dependent on the carotid arteries and by a direct interference of these drugs with the carotid sinus baro- and chemoreceptor structures. Moreover, these effects were not a result of the beta-adrenolytic properties of the drugs.

MeSH terms

  • Adrenergic beta-Antagonists / administration & dosage
  • Adrenergic beta-Antagonists / pharmacology*
  • Animals
  • Blood Pressure / drug effects
  • Carotid Arteries
  • Carotid Sinus / drug effects*
  • Chemoreceptor Cells / drug effects*
  • Denervation
  • Dogs
  • Female
  • Injections, Intra-Arterial
  • Male
  • Pressoreceptors / drug effects*
  • Respiration / drug effects

Substances

  • Adrenergic beta-Antagonists