Immunological and pharmacological monitoring in the clinical use of cyclosporin A

Lancet. 1981 Mar 28;1(8222):686-9. doi: 10.1016/s0140-6736(81)91971-1.


Immunological reactivity to donor antigens and serum concentrations of cyclosporin A were monitored in six patients after renal transplantation. At concentrations of 0.1--1.0 microgram/ml cyclosporin A prevented both donor-specific immune reactivity and clinical rejection during the early post-transplant course. Measurement of cyclosporin A levels and immunological indices allowed individual adjustment of the dosage so as to give excellent early graft function with few adverse effects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cyclosporins
  • Graft Survival / drug effects
  • Humans
  • Immunosuppressive Agents / blood*
  • Immunosuppressive Agents / immunology
  • Kidney Transplantation*
  • Peptides, Cyclic / blood*
  • Peptides, Cyclic / immunology
  • T-Lymphocytes / drug effects
  • Transplantation, Homologous


  • Cyclosporins
  • Immunosuppressive Agents
  • Peptides, Cyclic