Dynorphin: a possible modulatory peptide on morphine or beta-endorphin analgesia in mouse

Eur J Pharmacol. 1981 Jan 29;69(3):357-60. doi: 10.1016/0014-2999(81)90483-0.

Abstract

Dynorphin-(1-13), but not dynorphin-(1-9) has been shown to have significant effects on opiate and beta-endorphin-induced analgesia despite not having any appreciable analgesic activity itself. Dynorphin had no effect on Sandoz FK33824 compound-induced analgesia.

MeSH terms

  • Analgesics*
  • Animals
  • Drug Interactions
  • Dynorphins
  • Endorphins / administration & dosage
  • Endorphins / pharmacology*
  • Injections, Intraventricular
  • Male
  • Mice
  • Morphine / administration & dosage
  • Morphine / pharmacology*
  • Reaction Time / drug effects
  • Time Factors
  • beta-Endorphin

Substances

  • Analgesics
  • Endorphins
  • beta-Endorphin
  • Dynorphins
  • Morphine