Neuroleptic malignant syndrome-like state following a withdrawal of antiparkinsonian drugs

J Nerv Ment Dis. 1981 May;169(5):324-7. doi: 10.1097/00005053-198105000-00011.


A 63-year-old woman with diagnosis of Parkinson's disease developed an unusual symptom complex which consisted of extrapyramidal symptoms, disturbances of consciousness, diaphoresis, fever, and increased serum creatine phosphokinase following the discontinuation of large doses of combined antiparkinsonian drugs. After the patient's condition did not improve with the first 14 days of treatment consisting of intravenous fluids and antibiotics, a trial administration of L-dopa and carbidopa brought about definite clinical improvement. The symptoms strongly resembled neuroleptic malignant syndrome which is often a serious complication of antipsychotic drugs. The symptoms and the treatment of the present case suggest that dopaminergic hypoactivity in the brain may be an important factor in antiparkinsonian drug withdrawal syndrome and that similar neurochemical mechanisms may exist in neuroleptic malignant syndrome.

Publication types

  • Case Reports

MeSH terms

  • Antiparkinson Agents / adverse effects*
  • Antipsychotic Agents / adverse effects*
  • Body Temperature Regulation / drug effects
  • Creatine Kinase / blood
  • Drug Therapy, Combination
  • Dyskinesia, Drug-Induced / etiology
  • Electroencephalography
  • Evoked Potentials / drug effects
  • Female
  • Humans
  • Middle Aged
  • Parkinson Disease / drug therapy
  • Substance Withdrawal Syndrome / etiology*
  • Unconsciousness / chemically induced


  • Antiparkinson Agents
  • Antipsychotic Agents
  • Creatine Kinase