Some patients with cerebral aneurysms are deficient in type III collagen

Lancet. 1981 May 2;1(8227):973-5. doi: 10.1016/s0140-6736(81)91735-9.


Polyacrylamide gel electrophoresis of pepsin-digested skin biopsy specimens and carboxymethyl cellulose chromatography of radioactively labelled collagens produced by cultured fibroblasts demonstrated that 7 of 12 patients with congenital cerebral aneurysms were type III collagen deficient. This suggests that some cerebral aneurysms resemble various inherited defects of connective tissue-i.e., Ehlers-Danlos syndrome type IV-in which type III collagen deficiency causes arterial fragility.

MeSH terms

  • Cerebral Hemorrhage / etiology
  • Collagen / classification
  • Collagen / deficiency*
  • Collagen / genetics
  • Humans
  • Intracranial Aneurysm / congenital*
  • Intracranial Aneurysm / etiology
  • Intracranial Aneurysm / genetics


  • Collagen