Reevaluation of C-reactive protein in cancer sera by radioimmunoassay and radial immunodiffusion. I. Diagnostic value and use in battery of conventional tumor markers

Oncology. 1981;38(5):286-91. doi: 10.1159/000225572.


C-reactive protein (CRP) has been found to be ubiquitous in sera when determined by a highly sensitive methods such as radioimmunoassay. Patients with some tumors appear to have much higher serum levels of CRP than others; in these, CRP seems to reflect the tumor burden. There is a positive correlation with TNM staging and the disease activity a the time of determination. CRP shows a high degree of 'uniqueness' when correlated with other routinely used cancer markers such as carcinoembryonic antigen, placental-like alkaline phosphatase and gamma-glutamyltranspeptidase.

Publication types

  • Comparative Study

MeSH terms

  • Alkaline Phosphatase / blood
  • Breast Neoplasms / blood
  • C-Reactive Protein / analysis*
  • Carcinoembryonic Antigen / analysis
  • Colonic Neoplasms / blood
  • Female
  • Humans
  • Immunodiffusion
  • Neoplasms / blood*
  • Ovarian Neoplasms / blood
  • Radioimmunoassay
  • Uterine Neoplasms / blood
  • gamma-Glutamyltransferase / blood


  • Carcinoembryonic Antigen
  • C-Reactive Protein
  • gamma-Glutamyltransferase
  • Alkaline Phosphatase