HLA restricted virus-specific cytotoxic T-lymphocyte responses to live and inactivated influenza vaccines

Lancet. 1981 Oct 24;2(8252):887-91. doi: 10.1016/s0140-6736(81)91389-1.


36 young adult volunteers were given either virus, or inactivated surface-antigen influenza vaccine, containing influenza A (H1N1) antigen. Their peripheral-blood lymphocytes were analysed to determine whether cytotoxic T lymphocytes (CTL) were induced by these vaccines. All three vaccines induced HLA-restricted T-lymphocyte responses specific for influenza A virus. This CTL response was found in 28 of 30 volunteers who showed antibody responses and in 3 of 6 who did not develop antibodies. Virus infected target cells showing certain HLA antigens (A1, A9, and B8) were less susceptible to lysis by HLA-matched cytotoxic T effector cells than target cells which matched effectors at other HLA loci.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antigens, Surface / immunology
  • Cytotoxicity, Immunologic
  • HLA Antigens / immunology*
  • Hemagglutinins, Viral / biosynthesis
  • Humans
  • Immunologic Memory
  • Influenza A virus / immunology*
  • Influenza Vaccines / immunology*
  • T-Lymphocytes / immunology*
  • Vaccines, Attenuated / immunology


  • Antigens, Surface
  • HLA Antigens
  • Hemagglutinins, Viral
  • Influenza Vaccines
  • Vaccines, Attenuated