Intestinal antibody responses after immunisation with cholera B subunit

Lancet. 1982 Feb 6;1(8267):305-8. doi: 10.1016/s0140-6736(82)91568-9.


In about 80% of Bangladeshi volunteers a single oral or intramuscular immunisation with a new cholera toxoid immunogen (B subunit) gave rise to a local intestinal secretory immunoglobulin A (IgA) antitoxin response as measured in intestinal-lavage fluid by enzyme-linked immunosorbent assay methods. The rise in IgA antitoxin titre was similar for both immunisation routes and was comparable to that seen after clinical cholera; however, the response persisted longer after oral than intramuscular immunisation. A second immunisation by either route evoked an antitoxin response which usually closely resembled that seen after the first immunisation.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Administration, Oral
  • Cholera Toxin / administration & dosage
  • Cholera Toxin / immunology*
  • Humans
  • Immunoglobulin A / biosynthesis*
  • Immunoglobulin A, Secretory / biosynthesis*
  • Injections, Intramuscular
  • Intestine, Small / immunology*
  • Toxoids / immunology*


  • Immunoglobulin A
  • Immunoglobulin A, Secretory
  • Toxoids
  • Cholera Toxin