Morphological identification of the agent of Korean haemorrhagic fever (Hantaan virus)as a member of the Bunyaviridae

Lancet. 1982 Apr 3;1(8275):765-8. doi: 10.1016/s0140-6736(82)91812-8.

Abstract

Korean haemorrhagic fever (KHF) (Hantaan virus), a rodent-borne viral illness, is an important cause of human disease throughout much of Asia and Eastern Europe. The agent responsible for KHF has not yet been conclusively identified. Plaque-purified KHF virus was concentrated and then banded in a potassium tartrate gradient. Material from the 1.17-1.19 g/ml band was examined by electron microscopy and particles with a morphology identical to that of the family Bunyaviridae were found. The particles were aggregated by KHF serum but not by saline solution or non-immune serum. Identification of KHF virus as a member of the family Bunyaviridae implies a potential for spread by arthropod vectors.

MeSH terms

  • Bunyaviridae / classification
  • Bunyaviridae / isolation & purification
  • Bunyaviridae / ultrastructure*
  • Hemorrhagic Fever with Renal Syndrome / microbiology*
  • Humans
  • Kidney Diseases / microbiology
  • Orthohantavirus / ultrastructure
  • Syndrome
  • Virus Cultivation