Acute myoglobinuric renal failure. A consequence of the neuroleptic malignant syndrome

Arch Intern Med. 1982 Mar;142(3):601-3.


Neuroleptic malignant syndrome and acute myoglobinuric renal failure developed in three patients after they had received a combination of a major tranquilizer and a tricyclic antidepressant or after a large dose of haloperidol. Rhabdomyolysis was demonstrated by biochemical methods as well as by a muscle biopsy. Myoglobinuria was confirmed by radioimmunodiffusion and also was verified in a necropsy specimen. Dehydration and drug interaction with tricyclic antidepressants seem to be predisposing factors. Renal function recovered when the patient survived the acute episode, but neurologic sequelae persisted. Recommendations that may avert further cases are made.

Publication types

  • Case Reports

MeSH terms

  • Acute Kidney Injury / chemically induced*
  • Acute Kidney Injury / pathology
  • Adult
  • Antidepressive Agents, Tricyclic / adverse effects*
  • Antipsychotic Agents / adverse effects*
  • Dehydration / complications
  • Female
  • Haloperidol / adverse effects*
  • Humans
  • Kidney Tubules / pathology
  • Male
  • Middle Aged
  • Myoglobinuria / chemically induced*
  • Myoglobinuria / diagnosis
  • Nervous System Diseases / chemically induced
  • Syndrome


  • Antidepressive Agents, Tricyclic
  • Antipsychotic Agents
  • Haloperidol