Aminergic receptors in Drosophila melanogaster: responsiveness of adenylate cyclase to putative neurotransmitters

J Neurochem. 1982 Jun;38(6):1542-50. doi: 10.1111/j.1471-4159.1982.tb06631.x.


Adenylate cyclase in Drosophila melanogaster heads is stimulated 5-6-fold by low concentrations of octopamine. The octopamine stimulation is inhibited by low concentrations of the alpha-adrenergic ligands phentolamine and dihydroergotamine and of chlorpromazine, but not by low concentrations of the beta-antagonist propranolol and by the alpha-antagonist yohimbine. d-Tubocurarine enhances the octopamine effect. Tyramine, norepinephrine, and epinephrine also stimulate the cyclase, probably via the octopamine receptor. Serotonin and dopamine stimulate Drosophila adenylate cyclase 1.3-1.4-fold; at least the latter putative neurotransmitter seems to interact with a receptor distinct from the octopamine receptor. Prolonged incubation with dopamine in vitro abolishes adenylate cyclase basal activity as well as responsiveness to guanyl nucleotides, NaF, and putative neurotransmitters.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adenylyl Cyclases / metabolism*
  • Animals
  • Drosophila melanogaster / metabolism*
  • Guanosine Triphosphate / pharmacology
  • Guanylyl Imidodiphosphate / pharmacology
  • Kinetics
  • Mutation
  • Neurotransmitter Agents / pharmacology*
  • Octopamine / pharmacology
  • Receptors, Dopamine / metabolism*
  • Receptors, Serotonin / metabolism*
  • Sodium Fluoride / pharmacology


  • Neurotransmitter Agents
  • Receptors, Dopamine
  • Receptors, Serotonin
  • Octopamine
  • Guanylyl Imidodiphosphate
  • Guanosine Triphosphate
  • Sodium Fluoride
  • Adenylyl Cyclases