Altered neuropeptide concentrations in cerebrospinal fluid of psychiatric patients

Brain Res. 1982 Apr 22;238(1):298-302. doi: 10.1016/0006-8993(82)90801-0.


Immunoreactive somatostatin, bombesin, and cholecystokinin were measured in cerebrospinal fluid of normal subjects and patients with anorexia nervosa, depression, mania, and schizophrenia. Somatostatin-like immunoreactivity was decreased in anorexic and depressed patients. Bombesin-like immunoreactivity tended to be decreased in schizophrenics. Cholecystokinin-like immunoreactivity did not differ between groups. These data suggest a possible function for neuropeptides in regulation of human behavior.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Anorexia Nervosa / cerebrospinal fluid
  • Bipolar Disorder / cerebrospinal fluid
  • Bombesin / cerebrospinal fluid*
  • Cholecystokinin / cerebrospinal fluid*
  • Depressive Disorder / cerebrospinal fluid
  • Female
  • Humans
  • Male
  • Mental Disorders / cerebrospinal fluid*
  • Peptides / cerebrospinal fluid*
  • Schizophrenia / cerebrospinal fluid
  • Somatostatin / cerebrospinal fluid*


  • Peptides
  • Somatostatin
  • Cholecystokinin
  • Bombesin