Imaging of brain tumors after administration of L-(N-13)glutamate: concise communication

J Nucl Med. 1982 Aug;23(8):682-7.

Abstract

Cyclotron-produced L-(N-13)glutamate was used to visualize malignant intracranial tumors in 12 pediatric patients who had evidence of recurrent disease as documented by computed transaxial tomography (TCT). Imaging was performed using a rectilinear scanner, gamma camera, or a positron-emission tomograph (PET). The results indicate that N-13 is rapidly taken up by a majority of brain tumors following the administration of L-(N-13)glutamate, and that N-13 uptake is correlated with breakdown of the blood-brain barrier as demonstrated by contrast TCT or pertechnetate (Tc-99m) studies. The feasibility of using this agent in conjunction with PET is established.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Blood-Brain Barrier
  • Brain Neoplasms / diagnostic imaging*
  • Child
  • Female
  • Glutamates*
  • Glutamic Acid
  • Humans
  • Male
  • Nitrogen Radioisotopes*
  • Sodium Pertechnetate Tc 99m
  • Technetium
  • Tomography, Emission-Computed / methods*
  • Tomography, X-Ray Computed

Substances

  • Glutamates
  • Nitrogen Radioisotopes
  • Glutamic Acid
  • Technetium
  • Sodium Pertechnetate Tc 99m