Naloxone-induced reduction of schizophrenic symptoms

Acta Psychiatr Scand. 1982 May;65(5):370-4. doi: 10.1111/j.1600-0447.1982.tb00858.x.


A schizophrenic patient was repeatedly treated with intravenous naloxone 0.04 mg or saline in a double-blind design. The Comprehensive Psychopathological Rating Scale was used to quantify the symptoms before and after each injection. Naloxone significantly reduced the symptoms temporarily, whereas saline was without effect.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antipsychotic Agents / therapeutic use
  • Double-Blind Method
  • Female
  • Humans
  • Naloxone / therapeutic use*
  • Psychiatric Status Rating Scales
  • Renal Dialysis
  • Schizophrenia / drug therapy*
  • Schizophrenic Psychology*


  • Antipsychotic Agents
  • Naloxone