Wearable artificial endocrine pancrease with needle-type glucose sensor

Lancet. 1982 Nov 20;2(8308):1129-31. doi: 10.1016/s0140-6736(82)92788-x.


Miniaturisation of the bedside artificial endocrine pancreas in necessary to provide a means of restoring physiological glycaemic excursions in diabetic patients in the long term. One of the remaining problems in producing such a sophisticated device is the difficulty in developing a sufficiently small glucose-monitoring system. A needle-type glucose sensor has been developed which is suitable for use in a closed-loop glycaemic control system. The wearable artificial endocrine pancreas, incorporating the needle-type glucose sensor, a computer calculating infusion rates of insulin, glucagon, or both, and infusion pumps, was tested in pancreatectomised dogs: the device produced perfect control of blood glucose for up to 7 days.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Glucose*
  • Dogs
  • Electrodes
  • Glucagon / administration & dosage
  • Glucose / administration & dosage
  • Hypoglycemia / prevention & control
  • Insulin Infusion Systems*
  • Microcomputers
  • Needles


  • Blood Glucose
  • Glucagon
  • Glucose