Inhibition of Aflatoxin-Initiated Preneoplastic Liver Lesions by Low Dietary Protein

Nutr Cancer. 1982;3(4):200-6. doi: 10.1080/01635588109513723.

Abstract

The development of aflatoxin B1-induced hepatic preneoplastic lesions was significantly modified by varying the level of dietary casein fed to animals during the post-dosing period. Using gamma-glutamyl transferase staining to identify areas of cellular alteration, we observed that animals fed a 5% casein diet showed a 75% reduction in lesion development as compared to animals fed a 20% casein diet. Increasing the level of dietary casein from 20% to 40% produced no further increase in response. The results of the study, showing an inhibition in the preneoplastic development by a reduction dietary casein after aflatoxin dosing, suggest that low dietary casein inhibits the promotional phase of the ultimate neoplastic response.

MeSH terms

  • Aflatoxin B1
  • Aflatoxins*
  • Animals
  • Caseins / administration & dosage
  • Caseins / adverse effects*
  • Liver / pathology
  • Liver Neoplasms, Experimental / chemically induced
  • Liver Neoplasms, Experimental / metabolism
  • Liver Neoplasms, Experimental / prevention & control*
  • Male
  • Precancerous Conditions / chemically induced
  • Precancerous Conditions / metabolism
  • Precancerous Conditions / prevention & control*
  • Rats
  • gamma-Glutamyltransferase / metabolism*

Substances

  • Aflatoxins
  • Caseins
  • Aflatoxin B1
  • gamma-Glutamyltransferase