Memory enhancement induced in chicks by L-prolyl-L-leucyl-glycinamide

Pharmacol Biochem Behav. 1982 Nov;17(5):893-6. doi: 10.1016/0091-3057(82)90467-1.

Abstract

Two-day-old chicks were injected either intraventricularly or intraperitoneally with saline or a L-prolyl-L-leucyl-glycinamide solution. This C-terminal tripeptide of oxytocin produced retrograde enhancement when injected centrally but not peripherally. Possible memory mechanisms are discussed in light of this peptide's relationship to oxytocin, MSH, and dopaminergic systems.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Avoidance Learning / drug effects
  • Chickens
  • Dose-Response Relationship, Drug
  • Injections, Intraventricular
  • MSH Release-Inhibiting Hormone / pharmacology*
  • Male
  • Memory / drug effects*
  • Oxytocin / pharmacology*
  • Retention, Psychology / drug effects*
  • Taste / drug effects

Substances

  • Oxytocin
  • MSH Release-Inhibiting Hormone