Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 2 (3-4), 293-301

Drosophila as a Tool for the Rapid Assessment of Chemicals for Teratogenicity

Drosophila as a Tool for the Rapid Assessment of Chemicals for Teratogenicity

R L Schuler et al. Teratog Carcinog Mutagen.

Abstract

Drosophila melanogaster is being investigated for its potential to aid in identifying priority chemicals for teratologic study. The method encompasses treating larvae over the entire metamorphosis period, i.e., from the egg through three instar stages to pupa formation, by incorporating the test chemical into the medium. Adult flies are systematically examined under a binocular microscope for external morphological anomalies. Data from treated flies can be compared with those from concurrent control flies using standard statistical tests. Results from this developmental work reveal a dramatic and reproducible response of Drosophila to various chemical treatments. Validation studies, testing known teratogens and nonteratogens, are necessary before such a system can be incorporated into existing teratologic screening regimens.

Similar articles

See all similar articles

Cited by 3 PubMed Central articles

LinkOut - more resources

Feedback