Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 2 (3-4), 313-8

Prescreening for Environmental Teratogens Using Cultured Mesenchymal Cells From the Human Embryonic Palate

Prescreening for Environmental Teratogens Using Cultured Mesenchymal Cells From the Human Embryonic Palate

R M Pratt et al. Teratog Carcinog Mutagen.

Abstract

Mesenchymal cells from the prefusion human embryonic palate have been established in culture and can be grown in either a serum-free hormone-supplemented medium or a serum-containing medium. The growth of these cells is quite rapid in culture and inhibited in a dose-dependent manner by most teratogens thus far tested, such as dexamethasone. These cells are highly sensitive to a variety of DNA synthetic and mitotic inhibitors. The responses of these cells are complementary to the ovarian tumor cell attachment assay of Braun et al [1, and in this volume]. When used in conjunction with the tumor cells, the overall reliability is greater than 90% with only one false-negative, allopurinol.

Similar articles

See all similar articles

Cited by 5 PubMed Central articles

LinkOut - more resources

Feedback