Comparative Study
doi: 10.4269/ajtmh.1983.32.31.
Antitrypanosomal activity of sinefungin
- PMID: 6130709
- DOI: 10.4269/ajtmh.1983.32.31
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Comparative Study
Antitrypanosomal activity of sinefungin
Am J Trop Med Hyg.
1983 Jan.
Abstract
Sinefungin, a naturally occurring antifungal antibiotic nucleoside containing an ornithine residue, linked by a C-C bond to C-5' of adenosine, cures mice infected with Trypanosoma brucei brucei, T. congolense, or T. vivax; the effect of the drug is more pronounced towards T. congolense. Anti-trypanosomal activity of sinefungin could be the result of the inhibition of transmethylation reactions or of polyamine biosynthesis--or both--in parasites.
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