Calcium channel modulation by neurotransmitters, enzymes and drugs

Nature. 1983 Feb 17-23;301(5901):569-74. doi: 10.1038/301569a0.

Abstract

Calcium channels in excitable membranes are of great importance for many cellular functions. Modulation of these channels by neurotransmitters and drugs regulates calcium influx into the cell and thereby alters the functional state of the cell. Recently it has become possible to measure properties of single calcium channels directly and to obtain evidence on mechanisms of their modulation.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Aplysia
  • Calcium / metabolism*
  • Calcium Channel Blockers / pharmacology
  • Cell Membrane Permeability
  • Cyclic AMP / metabolism
  • Humans
  • Ion Channels / drug effects*
  • Kinetics
  • Membrane Proteins / metabolism
  • Models, Biological
  • Myocardium / metabolism
  • Neurons / metabolism
  • Neurotransmitter Agents / pharmacology*
  • Phosphorylation
  • Receptors, Adrenergic, beta / metabolism
  • Verapamil / pharmacology

Substances

  • Calcium Channel Blockers
  • Ion Channels
  • Membrane Proteins
  • Neurotransmitter Agents
  • Receptors, Adrenergic, beta
  • Verapamil
  • Cyclic AMP
  • Calcium