An excitatory amino acid antagonist blocks cone input to sign-conserving second-order retinal neurons

Science. 1983 Mar 11;219(4589):1230-2. doi: 10.1126/science.6131536.


cis-2,3-Piperidinedicarboxylic acid (PDA), an excitatory amino acid antagonist, reversibly blocked cone input to OFF bipolars and horizontal cells, whereas ON bipolars were relatively unaffected. Kainic acid effects were also blocked, indicating a postsynaptic mechanism of action. The use of PDA helps to characterize one of two classes of excitatory amino acid synaptic receptors that mediate cone influence in the outer retina.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acids / physiology*
  • Animals
  • Kainic Acid / pharmacology
  • Necturus
  • Neurotransmitter Agents / physiology
  • Photoreceptor Cells / physiology*
  • Pipecolic Acids
  • Retina / cytology
  • Retina / physiology*


  • Amino Acids
  • Neurotransmitter Agents
  • Pipecolic Acids
  • 2,3-piperidinedicarboxylic acid
  • Kainic Acid