Lorazepam in children. A double-blind trial comparing lorazepam, diazepam, trimeprazine and placebo

Br J Anaesth. 1983 Apr;55(4):275-9. doi: 10.1093/bja/55.4.275.


One hundred patients aged 5-13 yr were randomly allocated to four groups in a double-blind study of premedication. Drugs studied were lorazepam, diazepam and trimeprazine. A placebo group was included. All the drugs appeared satisfactory as premedicants. Lorazepam induced the most sedation immediately after surgery, but by 4 h lorazepam and diazepam appeared similar. Lorazepam produced better amnesia than the other drugs. There were no untoward side-effects and no cardiorespiratory depression in any group. Lorazepam appears a suitable premedicant for children.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Amnesia
  • Anti-Anxiety Agents* / pharmacology
  • Child
  • Child, Preschool
  • Clinical Trials as Topic
  • Diazepam* / pharmacology
  • Double-Blind Method
  • Hemodynamics / drug effects
  • Humans
  • Lorazepam* / pharmacology
  • Preanesthetic Medication*
  • Random Allocation
  • Respiration / drug effects
  • Time Factors
  • Trimeprazine* / pharmacology


  • Anti-Anxiety Agents
  • Trimeprazine
  • Lorazepam
  • Diazepam