The interaction of Tetrahymena 30S dynein with bovine brain microtubules

J Submicrosc Cytol. 1983 Jan;15(1):199-200.


The binding of Tetrahymena 30S dynein to bovine brain microtubules has been examined. The dynein was bound by its B-end or ATP sensitive site with a stoichiometry of 1 dynein arm per 6 tubulin dimers. Addition of ATP released virtually all the dynein from the surface of the microtubule. Following hydrolysis of the ATP, the dynein reassociated with the microtubule.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenosine Triphosphatases / metabolism*
  • Adenosine Triphosphate / pharmacology
  • Alkaloids / pharmacology
  • Animals
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Binding Sites
  • Brain / metabolism
  • Cattle
  • Dyneins / metabolism*
  • Microtubules / metabolism*
  • Paclitaxel
  • Tetrahymena


  • Alkaloids
  • Antineoplastic Agents, Phytogenic
  • Adenosine Triphosphate
  • Adenosine Triphosphatases
  • Dyneins
  • Paclitaxel