Effects on nociceptive threshold and blood pressure of intrathecally administered morphine and alpha-adrenergic agonists

Neuropharmacology. 1983 Mar;22(3):309-15. doi: 10.1016/0028-3908(83)90245-9.

Abstract

In the present experiments, the time course of the analgesic response (tail flick in rats, skin twitch in cat) and blood pressure effects of intrathecally administered morphine and the alpha-agonists, clonidine and ST-91 were examined in rats and cats. The clonidine analogue, ST-91 has approximately 1/50 the lipid solubility of clonidine. Intrathecally administered morphine and morphine followed by naloxone had no effect on resting blood pressure in unanaesthetized cats and in rats and cats anaesthetized with chloralose-urethane. Inactive when given systemically, ST-91 had a powerful antinociceptive effect when given intrathecally. At analgesic doses, this alpha-agonist produced only a transient hypertension. At doses 4-6 times that required to produce a significant antinociceptive effect, a pressor effect was observed. Intrathecal injection of clonidine in smaller doses produced a transient hypotension, with significant pressor effects present with larger doses.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adrenergic alpha-Agonists / pharmacology*
  • Animals
  • Blood Pressure / drug effects*
  • Clonidine / analogs & derivatives
  • Clonidine / pharmacology
  • Injections, Spinal
  • Male
  • Morphine / pharmacology*
  • Nociceptors / drug effects*
  • Rats
  • Rats, Inbred Strains
  • Sensory Thresholds / drug effects
  • Species Specificity
  • Time Factors

Substances

  • Adrenergic alpha-Agonists
  • ST 91
  • Morphine
  • Clonidine