Paradoxical reactions to benzodiazepines

Br J Clin Pharmacol. 1981;11 Suppl 1(Suppl 1):99S-104S. doi: 10.1111/j.1365-2125.1981.tb01844.x.


1 The overall incidence of paradoxical responses to the benzodiazepines is extremely small, but a few controlled studies have been carried out which define the population at risk.

2 Such reactions tend to be idiosyncratic except possibly in patients with pre-rage personality, and do not seem to be associated with any predictable clinical indications.

MeSH terms

  • Aggression / drug effects
  • Anti-Anxiety Agents / adverse effects*
  • Behavior / drug effects
  • Benzodiazepines
  • Depressive Disorder / chemically induced
  • Hostility / drug effects
  • Humans
  • Rage / drug effects


  • Anti-Anxiety Agents
  • Benzodiazepines