Abstract
A technique was developed to selectively facilitate transmission through synapses near the tip of a drug-ejecting micropipette by increasing Ca2+ concentration in a small space surrounding the tip. By means of this technique, we found that antagonists of excitatory amino acids, cis-2,3-piperidine dicarboxylic acid, gamma-D-glutamylglycine and glutamic acid diethylester, blocked excitation induced in CA3 neurons by glutamate and by mossy fiber stimulation in thin hippocampal sections of the guinea pig.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acids / administration & dosage
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Amino Acids / pharmacology*
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Animals
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Calcium / pharmacology
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Dipeptides / pharmacology
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Drug Antagonism
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Evoked Potentials / drug effects
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Excitatory Amino Acid Antagonists
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Glutamates / pharmacology
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Glutamic Acid
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Guinea Pigs
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Hippocampus / drug effects
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Hippocampus / physiology*
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Microelectrodes
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Pipecolic Acids / pharmacology
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Synapses / drug effects
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Synapses / physiology*
Substances
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Amino Acids
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Dipeptides
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Excitatory Amino Acid Antagonists
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Glutamates
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Pipecolic Acids
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glutamic acid diethyl ester
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gamma-glutamylglycine
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Glutamic Acid
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2,3-piperidinedicarboxylic acid
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Calcium