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Clinical Trial
, 15 (6), 743-5

Ranitidine Influences the Uptake of Oral Midazolam

Clinical Trial

Ranitidine Influences the Uptake of Oral Midazolam

R J Elwood et al. Br J Clin Pharmacol.

Abstract

In a randomised crossover study in volunteers plasma midazolam levels were estimated for 24 h following 15 mg by mouth, either preceded by no medication or following 24 h therapy with ranitidine. Administration of the H2-receptor blocker significantly increased bioavailability of the benzodiazepine and resulted in higher plasma levels for the first 6 h after taking midazolam. This was accompanied by a greater soporific effect.

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References

    1. Anesth Analg. 1978 Jan-Feb;57(1):1-5 - PubMed
    1. Anesthesiology. 1978 Jul;49(1):41-3 - PubMed
    1. Anaesthesia. 1980 May;35(5):454-8 - PubMed
    1. Anaesthesia. 1981 Sep;36(9):868-73 - PubMed
    1. Anaesthesia. 1982 Jan;37(1):26-32 - PubMed

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