[Effect of ranitidine on secretion of gastric intrinsic factor and absorption of vitamin B 12]

Gastroenterol Clin Biol. 1983 Apr;7(4):381-4.
[Article in French]


The effects of ranitidine, a new potent histamine H2-receptor antagonist, on gastric intrinsic factor (IF) secretion and protein-bound cobalamin absorption were evaluated in 6 patients with duodenal ulcer, before, during and after discontinuation of ranitidine therapy. Oral ranitidine (150 mg twice a day) resulted in a non significant decrease of IF concentration and IF output but was responsible for malabsorption of protein-bound cobalamin. This malabsorption was reversible upon discontinuation of ranitidine. These results indicate that occurrence of cobalamin deficiency cannot be excluded during long-term ranitidine treatment and emphasize the need for careful follow-up in these patients.

MeSH terms

  • Adult
  • Anti-Ulcer Agents / pharmacology
  • Duodenal Ulcer / drug therapy
  • Furans / pharmacology*
  • Histamine H2 Antagonists / pharmacology*
  • Humans
  • Intestinal Absorption / drug effects*
  • Intrinsic Factor / metabolism*
  • Middle Aged
  • Ranitidine
  • Vitamin B 12 / metabolism*


  • Anti-Ulcer Agents
  • Furans
  • Histamine H2 Antagonists
  • Ranitidine
  • Intrinsic Factor
  • Vitamin B 12