Contribution of the genetic status of oxidative metabolism to variability in the plasma concentrations of beta-adrenoceptor blocking agents

Eur J Clin Pharmacol. 1983;24(6):797-9. doi: 10.1007/BF00607090.


The oxidative metabolism of bufuralol is under the same genetic control as that of debrisoquine and sparteine. 154 fasting volunteers received a 30 mg tablet of bufuralol and a blood sample was taken 3 h later. In poor metabolizers (8% of the sample) the plasma bufuralol concentrations were very high and the metabolite concentrations were low. The genetic oxidative status is a major source of interindividual variation in the plasma concentration of drugs that undergo oxidative metabolism.

MeSH terms

  • Adrenergic beta-Antagonists / blood*
  • Adult
  • Ethanolamines / blood
  • Female
  • Humans
  • Hydroxylation
  • Male
  • Methanol / blood
  • Oxidation-Reduction
  • Phenotype


  • Adrenergic beta-Antagonists
  • Ethanolamines
  • bufuralol
  • Methanol