Conversion of 2-beta-D-ribofuranosylselenazole-4-carboxamide to an analogue of NAD with potent IMP dehydrogenase-inhibitory properties

MeSH terms

• Animals
• Gas Chromatography-Mass Spectrometry
• IMP Dehydrogenase / antagonists & inhibitors*
• Ketone Oxidoreductases / antagonists & inhibitors*
• Leukemia P388 / drug therapy*
• Leukemia, Experimental / drug therapy*
• Mice
• NAD / analogs & derivatives*
• Organoselenium Compounds*
• Ribavirin* / analogs & derivatives
• Ribavirin* / toxicity
• Ribonucleosides* / chemical synthesis
• Ribonucleosides* / toxicity*
• Selenium / chemical synthesis
• Selenium / toxicity*