The clinical use of anticholinergic drugs as treatment for extrapyramidal side effects of neuroleptic drugs

J Clin Psychopharmacol. 1983 Oct;3(5):288-302.


The clinician using neuroleptic drugs for the treatment of psychotic patients must face a number of questions regarding whether and how to use anticholinergic drugs when extrapyramidal side effects appear. This article explores some of these questions, suggests how they might best be answered, reviews the studies which address the questions, and notes some of the deficiencies in the available data base. Strategies for anticholinergic drug use, given the limited information available, are offered.

MeSH terms

  • Antipsychotic Agents / adverse effects*
  • Antipsychotic Agents / blood
  • Basal Ganglia Diseases / chemically induced
  • Basal Ganglia Diseases / drug therapy*
  • Drug Interactions
  • Humans
  • Parasympatholytics / adverse effects
  • Parasympatholytics / therapeutic use*
  • Substance-Related Disorders


  • Antipsychotic Agents
  • Parasympatholytics