A randomized comparison of midazolam and diazepam for sedation in upper gastrointestinal endoscopy

Br J Anaesth. 1983 Nov;55(11):1095-101. doi: 10.1093/bja/55.11.1095.


One hundred and eighty-five patients were allocated at random to receive pethidine with diazepam (in an emulsion), or pethidine with midazolam i.v. as sedation for upper gastrointestinal endoscopy. Sedation and conditions for examination were comparable and satisfactory in both groups. Midazolam produced more amnesia (P = less than 0.001), and scored higher in patients' opinion (P = less than 0.001); it was associated with a slightly greater frequency of venous sequelae, but the difference in thrombophlebitis was not statistically significant. Recovery of sensory--motor performance, as assessed by Trieger test, was still incomplete 2 h after endoscopy with both drug regimens.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Amnesia
  • Anti-Anxiety Agents* / adverse effects
  • Anti-Anxiety Agents* / pharmacology
  • Benzodiazepines* / adverse effects
  • Benzodiazepines* / pharmacology
  • Cholangiopancreatography, Endoscopic Retrograde
  • Diazepam* / adverse effects
  • Diazepam* / pharmacology
  • Digestive System
  • Endoscopy*
  • Female
  • Humans
  • Hypnotics and Sedatives*
  • Male
  • Midazolam
  • Middle Aged
  • Patient Acceptance of Health Care
  • Random Allocation


  • Anti-Anxiety Agents
  • Hypnotics and Sedatives
  • Benzodiazepines
  • Diazepam
  • Midazolam