Effects of glutamate and aspartate on sympathetic preganglionic neurons in the upper thoracic intermediolateral nucleus of the cat

Brain Res. 1983 Oct 31;277(2):370-4. doi: 10.1016/0006-8993(83)90948-4.


Glutamate and aspartate excited all spontaneously active sympathetic preganglionic neurons (SPNs) tested in the intermediolateral nucleus of spinal segments T1-T3. Most silent neurons could be induced to discharge but the remainder showed only a decrease in antidromic spike amplitude. These effects were typically fast (on, off less than 1 s). D,L-Homocysteic acid also produced excitation; this effect was typically slower. Glutamate and aspartate were usually equipotent; 20% were differentially sensitive to aspartate, 10% to glutamate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aspartic Acid / pharmacology*
  • Autonomic Fibers, Preganglionic / drug effects*
  • Cats
  • Evoked Potentials / drug effects
  • Ganglia, Sympathetic / drug effects*
  • Glutamates / pharmacology*
  • Glutamic Acid
  • Homocysteine / analogs & derivatives
  • Homocysteine / pharmacology
  • Neurons / drug effects
  • Spinal Cord / drug effects*
  • Synapses / drug effects
  • Synaptic Transmission / drug effects*


  • Glutamates
  • Homocysteine
  • homocysteic acid
  • Aspartic Acid
  • Glutamic Acid