The involvement of 5-hydroxytryptamine in the release of dendritic dopamine from slices of rat substantia nigra

J Pharm Pharmacol. 1983 Nov;35(11):734-7. doi: 10.1111/j.2042-7158.1983.tb02880.x.

Abstract

[3H]dopamine (DA) accumulated by slices of rat substantia nigra was released following superfusion with Krebs solution containing 5-hydroxytryptamine (5-HT) in a dose-dependent fashion with maximal release being produced by 1 X 10(-4) M. This 5-HT-induced release of [3H]DA was calcium-dependent and was inhibited by pretreatment with the 5-HT antagonist cinanserin. These results are interpreted as supporting the possibility that 5-HT has a role in regulating dopaminergic activity in the nigro-striatal pathway.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calcium / physiology
  • Cinanserin / pharmacology
  • Dendrites / metabolism*
  • Dopamine / metabolism*
  • Female
  • In Vitro Techniques
  • Rats
  • Rats, Inbred Strains
  • Serotonin / physiology*
  • Substantia Nigra / metabolism*
  • Time Factors

Substances

  • Serotonin
  • Cinanserin
  • Calcium
  • Dopamine